| Rank | Player | Team | ER |
|---|---|---|---|
| 1 |  Patrick Corbin |  | 27 |
| 2 |  Justin Verlander |  | 23 |
| 3 |  Jameson Taillon |  | 21 |
| 4 |  Dinelson Lamet |  | 20 |
| 5 |  Carlos Rodon |  | 20 |
| 6 |  Lucas Giolito | | 19 |
| 7 |  Aaron Nola |  | 19 |
| 8 |  Gerrit Cole | | 19 |
| 9 |  Mike Clevinger | | 19 |
| 10 |  Hyun Jin Ryu | | 19 |
| 11 |  Shohei Ohtani | | 18 |
| 12 |  Justus Sheffield |  | 18 |
| 13 |  Dakota Hudson |  | 18 |
| 14 |  Chris Paddack | | 18 |
| 15 |  Miles Mikolas |  | 17 |
| 16 |  Rich Hill |  | 16 |
| 17 |  Robert Stephenson | | 16 |
| 18 |  Dane Dunning |  | 16 |
| 19 |  Max Fried |  | 16 |
| 20 |  Trevor WIlliams |  | 15 |
