| Rank | Player | Team | K |
|---|---|---|---|
| 1 |  Jake Arrieta |  | 47 |
| 2 |  Max Scherzer |  | 45 |
| 3 |  Miles Mikolas | | 39 |
| 4 |  Kyle Hendricks | | 38 |
| 5 |  Jacob deGrom |  | 38 |
| 6 |  Kenta Maeda |  | 35 |
| 7 |  Steven Matz |  | 29 |
| 8 |  Adbert Alzolay | | 29 |
| 9 |  Robbie Ray | | 27 |
| 10 |  Jack Flaherty |  | 25 |
| 11 |  Danny Duffy |  | 25 |
| 12 |  Noah Syndergaard | | 24 |
| 13 |  Lance Lynn |  | 23 |
| 14 |  Kwang Hyun Kim | | 23 |
| 15 |  James Paxton |  | 23 |
| 16 |  Cristian Javier |  | 23 |
| 17 |  Tyler Glasnow |  | 21 |
| 18 |  Gerrit Cole |  | 21 |
| 19 |  Trent Thornton | | 21 |
| 20 |  Dane Dunning |  | 20 |
