| Rank | Player | Team | L |
|---|---|---|---|
| 1 |  Dinelson Lamet |  | 6 |
| 2 |  Blake Snell | | 5 |
| 3 |  Justus Sheffield |  | 5 |
| 4 |  Patrick Corbin |  | 5 |
| 5 |  Jameson Taillon |  | 5 |
| 6 |  Mike Clevinger | | 5 |
| 7 |  Yu Darvish | | 4 |
| 8 |  Rich Hill |  | 4 |
| 9 | Mike Foltynewicz | | 4 |
| 10 |  Lucas Giolito |  | 4 |
| 11 |  Trevor WIlliams |  | 4 |
| 12 |  Carlos Rodon | | 4 |
| 13 |  Chris Paddack | | 4 |
| 14 |  Hyun Jin Ryu |  | 4 |
| 15 | Joe Gatto | | 3 |
| 16 |  Shohei Ohtani |  | 3 |
| 17 |  Carlos Martinez |  | 3 |
| 18 |  Kyle Freeland | | 3 |
| 19 |  Aaron Nola | | 3 |
| 20 |  Lance Lynn | | 3 |
